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Faculty of Dentistry
Document Details
Document Type
:
Article In Journal
Document Title
:
E-CADHERIN IMMUNOMODULATION IN NORMAL, HYPERPLASTIC AND DYSPLASTIC ORAL EPITHELIUM
E-CADHERIN IMMUNOMODULATION IN NORMAL, HYPERPLASTIC AND DYSPLASTIC ORAL EPITHELIUM
Document Language
:
English
Abstract
:
The expression of E-cadherin in normal oral epithelium, hyperkeratosis and leukoplakia was ex-amined immunohistochemically using a monoclonal anti-E-cadherin antibody. The results showed strong to moderate positive reaction for E-cadherin in the prickle cells and superficial cell layers of normal surface epithelium. The reaction was mainly localized to the cell membrane, but faint pos- itive staining can he seen through the cytoplasm. The hyperplastic epithelium of the hyperkeratotic lesions showed positive reaction for E-cadherin in the middle layers of prickle cells. The staining was localized to the cell membrane. The localization of E-cadherin in dysplastic epithelium of oral leukoplakia was variable in intensity and irregular in distribution within the epithelial layers. In gen- eral, the presence of E-cadherin is decreased with increasing severity of epithelial dysplasia. It was concluded that, E-cadherin may be used as a biomarker for evaluation of oral premalignant lesions. * Ass. Prof., Oral Pathology, Faculty Of Dentistry Alexandria University.
ISSN
:
0
Journal Name
:
Egyptian Dental Journal
Volume
:
7
Issue Number
:
3
Publishing Year
:
1422 AH
2002 AD
Article Type
:
Article
Added Date
:
Monday, May 5, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زينب درويش
Darwish, Zeinab
Researcher
Doctorate
zdarweesh@kau.edu.sa
Files
File Name
Type
Description
E-CADHERIN IMMUNOMODULATION IN NORMAL.pdf
pdf
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