Document Details

Document Type : Thesis 
Document Title :
Study of Mutagenic Effect of Carboplatin on Somatic and Germinal Cells of Male Albino Mice
دراسة التأثير المطفر لعقار الكاربوبلاتين على الخلايا الجسدية والجرثومية لذكور الفئران البيضاء
 
Subject : biological sciences department 
Document Language : Arabic 
Abstract : Genotoxicity of carboplatin was assayed in somatic and germ cells of adult male swiss albino mice, Mus musculus.Genotoxicity and cytotoxicity was evaluated by micronucleus test and sperm-head abnormalities test. Three doses were used, a sub - cute therapeutic dose (2mg\kg), double the therapeutic dose (4mg\kg) and five times the therapeutic dose (10mg\kg) . Mice has been treated in each of the micronucleus test and sperm-head abnormalities test for five consecutive days by injection into the intraperitonealinjection. Results showedsignificantincreasein the micronucleus test on bone marrow also in the sperm-head abnormalities test in two stages: Late spermatids and Secondary spermatocytes. The overall results suggest a positive relationship between dose and occurrence of both micronucleus test in bone marrow and sperm -head abnormalities test. From this, the ability of the drug mutagenicity can be concluded. This mutagenic strength can access to somatic and germ cell which give the ability of transmition to the next generations. 
Supervisor : Dr. Salwa Mohammad Quita 
Thesis Type : Master Thesis 
Publishing Year : 1433 AH
2012 AD 
Co-Supervisor : Dr. Mohammed Zainy Mutawakal 
Added Date : Tuesday, July 10, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
بدرية عبدالله حفنيHifni, Badriah AbdullahResearcherMaster 

Files

File NameTypeDescription
 33912.pdf pdf 

Back To Researches Page