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Faculty of Dentistry
Document Details
Document Type
:
Article In Journal
Document Title
:
COMPARATIVE IMMUNOHISTOCHEMICAL STUDY ON OSTEOCALCIN EXPRESSION IN FIBROUS DYSPLASIA AND OSSIFYING FIBROMA
COMPARATIVE IMMUNOHISTOCHEMICAL STUDY ON OSTEOCALCIN EXPRESSION IN FIBROUS DYSPLASIA AND OSSIFYING FIBROMA
Document Language
:
English
Abstract
:
Objective: Fibrous dysplasia (FD) and ossifying fibroma (OF) show similar histological and radiological features, making distinction between them a diagnostic dilemma requiring clarification. Study Design: Forty (20 FD, 20 OF) paraffin-embedded specimens were immunohistochemically stained using the primary antibody Osteocalcin (OC). The immunostained area fraction was evaluated in the bone trabeculae alone and in both the bone trabeculae and the connective tissue stroma together. Results: All cases of FD and OF demonstrated OC immunostaining in both the bone trabeculae and the stromal cells. In FD, osteocalcin was more expressed in stromal cells, while in OF, immunoreactivity was more marked in bone trabeculae. The area fraction expressing OC in both the bone tarbeculae and fibrous stroma was significantly higher in FD than OF (p= 0.025). Conclusion: The stromal spindle-shaped cells in FD are of the osteoblastic lineage. Osteocalcin expression can be a significant support in differential diagnosis of FD and OF.
ISSN
:
1359-8546
Journal Name
:
INTERNATiONAL JOURNAL of ACADEMIC RESEARCH
Volume
:
5
Issue Number
:
1
Publishing Year
:
1434 AH
2013 AD
Article Type
:
Article
Added Date
:
Monday, December 10, 2012
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
عواطف دازار
Dzar, Awatef
Researcher
Doctorate
Files
File Name
Type
Description
34682.pdf
pdf
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