Document Details

Document Type : Article In Journal 
Document Title :
A Brief Overview of Tyrosine Hydroxylase and α-synuclein in the Parkinsonian brain
مراجعة موجزة لدور هيدروكسيلاز التايروسين والدوبامين في مخ المصابين بمرض باركنسون
 
Subject : Parkinson 
Document Language : English 
Abstract : Parkinsons disease (PD) is associated with neurodegeneration of the nigrostriatal tract and is accompanied with loss of tyrosine hydroxylase (TH) and dopamine (DA). Development of neuroprotective strategies targeting PD is often undermined by lack of proper understanding of processes contributing to the pathology. In this mini review we have tried to briefly outline the involvement of TH and α-synuclein in PD. Aberrant expression of α-synuclein is toxic to dopaminergic neurons. It interacts with ubiquitin-proteasomal processing, oxidative injury and mitochondrial dysfunction to induce neurodegenration and cell death. The contributions of DJ-1 in TH regulation have also been discussed. Brain specific TH expression with the combined use of the pegylated immunoliposome (PILs) gene transfer technology and brain specific promoters as a new approach to treat PD has also been included 
ISSN : 5273-1871 
Journal Name : CNS & Neurological Disorder-Drug Targets 
Volume : 11 
Issue Number : 8 
Publishing Year : 1433 AH
2012 AD 
Article Type : Review Article 
Added Date : Tuesday, June 19, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
هيثم أحمد زكائيZakai, Haytham AhmedResearcherDoctoratehzakai@kau.edu.sa
وجيه الله رضا الله خانkhan, wajihullah redhallahInvestigatorDoctoratewajihullahkhan@yahoo.co.in
ميضاء بريدارشينيPriyadashini, Medha ResearcherDoctorate 
محمد كمالKamal, Mohammed ResearcherDoctorate 
قمر علمAlem, Qamre ResearcherDoctorate 

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