Document Details

Document Type : Article In Journal 
Document Title :
Understanding the molecular mechanism (s) of hepatitis C virus (HCV) induced interferon resistance
Understanding the molecular mechanism (s) of hepatitis C virus (HCV) induced interferon resistance
 
Document Language : English 
Abstract : Hepatitis C virus (HCV) is one of the foremost causes of chronic liver disease affecting over 300 million globally. HCV contains a positive-stranded RNA of ~9600 nt and is surrounded by the 5' and 3'untranslated regions (UTR). The only successful treatment regimen includes interferon (IFN) and ribavirin. Like many other viruses, HCV has also evolved various mechanisms to circumvent the IFN response by blocking (1) downstream signaling actions via STAT1, STAT2, IRF9 and JAK-STAT pathways and (2) repertoire of IFN Stimulatory Genes (ISGs). Several studies have identified complex host demographic and genetic factors as well as viral genetic heterogeneity associated with outcomes of IFN therapy. The genetic predispositions of over 2000 ISGS may render the patients to become resistant, thus identification of such parameters within a subset of population are necessary for management corollary. The ability of various HCV genotypes to diminish IFN antiviral responses plays critical role in the establishment of chronic infection at the acute stage of infection, thus highlighting importance of the resistance in HCV treated groups. The recently defined role of viral protein such as C, E2, NS3/NS4 and NS5A proteins in inducing the IFN resistance are discussed in this article. How the viral and host genetic composition and epistatic connectivity among polymorphic genomic sites synchronizes the evolutionary IFN resistance trend remains under investigation. However, these signals may have the potential to be employed for accurate prediction of therapeutic outcomes. In this review article, we accentuate the significance of host and viral components in IFN resistance with the aim to determine the successful outcome in patients. 
ISSN : 1567-1348 
Journal Name : Infection, Genetics and Evolution 
Volume : 19 
Issue Number : 1 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Thursday, March 10, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Hanadi QashqariQashqari, Hanadi Researcher  
Amany Al-MarsAl-Mars, Amany Researcher  
Adeel ChaudharyChaudhary, Adeel Researcher  
Adel AbuzenadahAbuzenadah, Adel Researcher  
Ghazi DamanhouriDamanhouri, Ghazi Researcher  
Mohammed AlQahtaniAlQahtani, Mohammad Researcher  
Maged MahmoudMahmoud, Maged Researcher  
Maysaa El Sayed ZakiZaki, Maysaa El Sayed Researcher  
Kaneez FatimaFatima, Kaneez Researcher  
Ishtiaq QadriQadri, Ishtiaq Researcher  

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