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Document Details
Document Type
:
Article In Journal
Document Title
:
Synthesis of 1-p-sulfamylphenyl-3-trifluoromethylpyrazoles class of cyclooxygenase-2 inhibitors.
Synthesis of 1-p-sulfamylphenyl-3-trifluoromethylpyrazoles class of cyclooxygenase-2 inhibitors.
Document Language
:
Arabic
Abstract
:
Condensation of p-sulfamylphenylhydrazine with diketones 1 afforded pyrazoles 2. Reaction of 2 with isocyanate and isothiocyanate derivatives gave the corresponding ureas 3 and thioureas 4 respectively. Cyclization of the thioureido group of compounds 4 by treating with ethyl bromoacetate, ethyl beta-bromopropionate and alpha- bromoacetophenone afforded the corresponding thiazolidinone, thiazinone and thiazoline derivatives 5, 6 and 7 respectively.
Journal Name
:
HETEROCYCLIC COMMUNICATIONS
Volume
:
9
Issue Number
:
5
Publishing Year
:
2003 AH
Added Date
:
Saturday, June 14, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أ.د.عبد الله بن محمـد أحمـد عسيــــري
Asiri AM
Researcher
.
Faidallah HM
Researcher
.
Albar HM
Researcher
.
Sharshira EM
Researcher
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