Document Details

Document Type : Article In Journal 
Document Title :
Microwave-assisted chemical ligation of S-acyl peptides containing non-terminal cysteine residues
Microwave-assisted chemical ligation of S-acyl peptides containing non-terminal cysteine residues
 
Subject : Chemistry 
Document Language : English 
Abstract : An efficient approach for the synthesis of a series of S-acyl peptides containing internal cysteine residues has been developed and the chemical long-range ligation of these S-acyl peptides via 5-, 8-, 11- and 14-membered cyclic transition states has been investigated. Our results include the first examples of successful isopeptide ligations starting from S-acyl peptides containing non-terminal cysteine residues and indicate that the cyclic transition states studied in this present paper are decreasingly favored in the order of their sizes 5≫14>11≫8. 
ISSN : 1477-0520 
Journal Name : Organic and Biomolecular Chemistry 
Volume : 9 
Issue Number : 20 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Wednesday, April 18, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
F K HansenHansen, F KResearcherDoctorate 
K HaHa, K ResearcherDoctorate 
E TodadzeTodadze, E ResearcherDoctorate 
A LillicotchLillicotch, A ResearcherDoctorate 
A FreyFrey, A ResearcherDoctorate 
Alan Roy KatritzkyKatritzky, Alan RoyResearcherDoctoratekatritzky@chem.ufl.edu

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