Faculty of Sciences | Researches | Introducing lasso peptides as molecular scaffolds for drug design: Engineering of an integrin antagonist

Faculty of Sciences

Document Details

Document Type	:	Article In Journal
Document Title	:	Introducing lasso peptides as molecular scaffolds for drug design: Engineering of an integrin antagonist Introducing lasso peptides as molecular scaffolds for drug design: Engineering of an integrin antagonist
Subject	:	Chemistry
Document Language	:	English
Abstract	:	Tightening the noose: Lasso peptides are a class of stable bacterial peptides with unique characteristics that encourage their application in drug design. Epitope grafting of the integrin binding motif RGD onto the lasso structure of microcin J25 converts the knotted peptide into a nanomolar integrin antagonist (see picture). Engineered lasso peptides can therefore be used for pharmacophore presentation.
ISSN	:	14337851
Journal Name	:	Angewandte Chemie - International Edition
Volume	:	50
Issue Number	:	37
Publishing Year	:	1432 AH 2011 AD
Article Type	:	Article
Added Date	:	Sunday, April 29, 2012

Researchers

Researcher Name (Arabic)	Researcher Name (English)	Researcher Type	Dr Grade	Email
T A Knappe	Knappe, T A	Researcher	Doctorate
Horst Kessler	Kessler, Horst	Researcher	Doctorate	Kessler@tum.de

Files

File Name	Type	Description
33048.pdf	pdf	Abstract

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