Document Details

Document Type : Article In Journal 
Document Title :
Comparative Analysis of Syntenic Genes in Grass Genomes Reveals Accelerated Rates of Gene Structure and Coding Sequence Evolution in Polyploid Wheat
Comparative Analysis of Syntenic Genes in Grass Genomes Reveals Accelerated Rates of Gene Structure and Coding Sequence Evolution in Polyploid Wheat
 
Document Language : English 
Abstract : Cycles of whole-genome duplication (WGD) and diploidization are hallmarks of eukaryotic genome evolution and speciation. Polyploid wheat (Triticum aestivum) has had a massive increase in genome size largely due to recent WGDs. How these processes may impact the dynamics of gene evolution was studied by comparing the patterns of gene structure changes, alternative splicing (AS), and codon substitution rates among wheat and model grass genomes. In orthologous gene sets, significantly more acquired and lost exonic sequences were detected in wheat than in model grasses. In wheat, 35% of these gene structure rearrangements resulted in frame-shift mutations and premature termination codons. An increased codon mutation rate in the wheat lineage compared with Brachypodium distachyon was found for 17% of orthologs. The discovery of premature termination codons in 38% of expressed genes was consistent with ongoing pseudogenization of the wheat genome. The rates of AS within the individual wheat subgenomes (21%-25%) were similar to diploid plants. However, we uncovered a high level of AS pattern divergence between the duplicated homeologous copies of genes. Our results are consistent with the accelerated accumulation of AS isoforms, nonsynonymous mutations, and gene structure rearrangements in the wheat lineage, likely due to genetic redundancy created by WGDs. Whereas these processes mostly contribute to the degeneration of a duplicated genome and its diploidization, they have the potential to facilitate the origin of new functional variations, which, upon selection in the evolutionary lineage, may play an important role in the origin of novel traits. 
ISSN : 0032-0889 
Journal Name : PLANT PHYSIOLOGY 
Volume : 161 
Issue Number : 1 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Tuesday, July 25, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Eduard AkhunovAkhunov, Eduard Researcher  
Sunish SehgalSehgal, Sunish Researcher  
Hanquan LiangLiang, Hanquan Researcher  
Shichen WangWang, Shichen Researcher  
Alina AkhunovaAkhunova, Alina Researcher  
Gaganpreet KaurKaur, Gaganpreet Researcher  
Wanlong LiLi, Wanlong Researcher  
Kerrie ForrestForrest, Kerrie Researcher  
Deven SeeSee, Deven Researcher  
Hanaa SimkovaSimkova, Hana Researcher  
Yaqin MaMa, Yaqin Researcher  
Matthew HaydenHayden, Matthew Researcher  
Mingcheng LuoLuo, Mingcheng Researcher  
Justin FarisFaris, Justin Researcher  
Jaroslav DolezelDolezel, Jaroslav Researcher  
Bikram GillGill, Bikram Researcher  

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