Document Details

Document Type : Article In Journal 
Document Title :
Chlorambucil therapy in children with steroid-resistant nephrotic syndrome.
إستخدام عقار الكلوراميوسيل في علاج الأطفال الذين يعانون من متلازمة كلوية المقاومة الستيرويد
 
Document Language : English 
Abstract : Chlorambucil (CHL) had been used as treatment for childhood nephrotic syndrome (NS) for more than half a century.1 It was used mainly in children with steroid sensitive nephrotic syndrome (SSNS) as steroid sparing agent in those with frequent relapsing or steroid dependent course. However, it was observed to result in higher rates of severe side effects and recommended as a second line drug after cyclophosphamide (CYC), which is considered as safer alkylating agent. The alkylating agents have been used for treating steroid resistant nephrotic syndrome (SRNS). In this retrospective study, we report our results of using CHL in children with SRNS secondary to IgM nephropathy, FSGS or diffuse mesangial hypercellularity (DMH). All patients presented to our unit over 20 months period (from February 2002 until June 2004) and were diagnosed as SRNS were recruited. We conclude that CHL therapy in a total accumulative dose of 15 mg/kg and 12 weeks duration could achieve complete remission in children with SRNS secondary to IgM nephropathy. Further randomized controlled studies are required 
ISSN : 8832-1012 
Journal Name : Saudi Med J. 
Volume : 4 
Issue Number : 27 
Publishing Year : 2006 AH
2006 AD 
Article Type : Article 
Added Date : Wednesday, March 10, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جميلة قاريKari, Jameela ResearcherDoctorate 

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 25861.doc doc 

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