Document Details

Document Type : Article In Journal 
Document Title :
Severe proximal myopathy with remarkable recovery after vitamin D treatment.
استخدام فيتامين د لعلاج وهن العضلات الشديد
 
Document Language : English 
Abstract : Background: Osteomalacia is an uncommon cause of muscle weakness. Our objectives were to describe features of myopathy associated with Vitamin D deficiency and examine the contributing factors leading to osteomalacic myopathy in our region. Methods: A series of consecutive patients with proximal myopathy associated with vitamin D deficiency were identified retrospectively over a 6 year period ending December, 2006. Patients were followed in 3 major centers in western Saudi Arabia. Clinical, biochemical, radiological, and electrophysiological findings were collected before and after Vitamin D treatment by chart review. Results: Forty seven female patients aged 13-46 years (mean 23.5, SD 4.5) were included. All were veiled and covered heavily when outside the house for social and cultural reasons. Only 8 (17%) had adequate varied diet with daily milk ingestion. All patients presented with progressive proximal muscle weakness lasting 6-24 months (mean 14) prior to our evaluation. The weakness was severe in 6 (13%) patients leading to wheel chair bound states. Associated musculoskeletal pain involving the back, hips, or lower limbs was common (66%). Osteomalcia was the referral diagnosis in only 11 patients and the remaining 36 (77%) patients were misdiagnosed. All patients had metabolic and radiological profiles suggestive of osteomalacia. Remarkable recovery was documented in all patients following oral cholecalciferol and calcium supplementation. Conclusions: Vitamin D deficiency is an important treatable cause of osteomalacic myopathy in Saudi Arabia. The diagnosis is frequently delayed or missed. Screening for Vitamin D deficiency in patients with acquired myopathy is needed to identify this treatable disorder. 
ISSN : 0306-4522 
Journal Name : Canadian Journal of Neurological Sciences 
Volume : 3 
Issue Number : 36 
Publishing Year : 2009 AH
2009 AD 
Article Type : Article 
Added Date : Wednesday, March 10, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمد جانjan, Mohammed ResearcherDoctorate 

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