Document Details Document Type : Article In Journal  Document Title : METABOLIC CHANGES IN MELATONIN AND HIGH FAT DIET -TREATED RATS METABOLIC CHANGES IN MELATONIN AND HIGH FAT DIET -TREATED RATS   Document Language : English  Abstract : This work was carried out to study the effect of melatonin on carbohydrate and lipid metabolism in male albino rats. Animals were divided into 4 groups. Control group, melatonin¬treated group, high fat fed-group, and high fat+melatonin treated group. Plasma glucose and insulin levels as well as glucose uptake by skeletal muscle (diaphragm) were assessed. In addition plasma lipoproteins profile as plasma triglycerides (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein- cholesterol (HDL-C) were also measured. Melatonin-treated+normally fed group showed significant hyperglycemia, while the changes in glucose uptake and plasma lipoproteins were statistically insignificant. On the other hand, melatonin administration to rats fed high fat diet resulted in significant hyperglycemia and significant decrease in glucose uptake together with significant reduction in plasma insulin level compared to diet matched group. Also melatonin resulted in significant reduction of TG, TC, and LDL-C associated with significant increase in HDL-C plasma levels. It is concluded that melatonin administration was associated with hyperglycemia, decrease glucose uptake and hypolipidemia. Such effect was marked when it is administered to rats on high fat diet.  ISSN : 0940-5429  Journal Name : EGYPTIAN JOURNAL OF APPLIED ENDOCRINOLOGY  Volume : 21  Issue Number : 1  Publishing Year : 2003 AH 2003 AD  Article Type : Article  Added Date : Sunday, March 21, 2010  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email عاطف موسى عبود Abood, Atef M Researcher Doctorate   Files File Name Type Description  26128.8 8   Back To Researches Page