Document Details

Document Type : Article In Journal 
Document Title :
Trace elements status in diabetic patients with and without atherosclerosis
Trace elements status in diabetic patients with and without atherosclerosis
 
Document Language : English 
Abstract : Background of Study: Increased coronary risk in diabetic patients is attributed to multiple risk factors. Endothelial dysfunction and inflammation are present in both type 2 diabetes mellitus (DM) and coronary artery disease (CAD). Various inflammatory markers and adhesion molecules have been proposed to assist in the prediction of subsequent coronary events among cardiovascular patients. Serum copper level has been suggested to be an independent coronary risk factor in animals. Copper/ zinc ratio is also thought to be important. DM can lead to deficiency of micronutrients due to diuresis. Objectives: To compare several inflammatory markers along with copper and zinc status in diabetic Saudi males with and without atherosclerosis in the hope of improving the management of diabetes mellitus to avoid or delay CAD. Methods: 404 subjects were recruited from two major hospitals in Jeddah and classified into 4 groups; non-diabetic controls, diabetic controls, non-diabetic atherosclerotics and diabetic atherosclerotics. Fasting blood samples were taken to measure hs-CRP, sICAM-1, and Cp, superoxide dismutase (SOD) enzyme activity, lipid peroxides using Fox assay, and copper (Cu) and zinc (Zn). One-way analysis of variance was used to compare mean values among the groups followed by the post-hoc multiple comparison tests. Results: Lower serum Zn levels were found in diabetic controls verses non-diabetic controls (p<0.01). Lower serum Cu and Zn levels as well as and serum Cu/Zn ratio were found in diabetic cases verses non-diabetic controls (p<0.01). Lower erythrocytes SOD activity was found in diabetic cases verses non-diabetic controls (p<0.01). Serum Cp, hs-CRP and lipid peroxides levels showed to be higher in diabetic cases verses non-diabetic controls (p<0.01). Conclusions: DM seems to be associated with Zn depletion reflected on lower serum Zn level. When Cu status is also compromised in diabetic patients, leading to decreased Cu/Zn ratio, this causes decreased activities of the antioxidant enzyme SOD and reflected on increased lipid peroxides levels. This might have increased inflammation as demonstrated by increased serum levels of CRP, Cp, and sICAM-1. Cu and Zn intake and status must be monitored in diabetic patients to avoid or delay the complications of atherosclerosis. Determination of adequate intake and proper Cu/Zn ratio need further research. 
ISSN : 9466032 
Journal Name : Proceedings of the 12th international congress of endocrinology 
Volume : 1 
Issue Number : 1 
Publishing Year : 2004 AH
2004 AD 
Article Type : Article 
Added Date : Wednesday, March 24, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سهاد باحجريBAHIJRI, SUHAD ResearcherDoctorate 

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