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Document Type |
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Article In Journal |
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Document Title |
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The mechanism of chromium - insulin interaction: a door to novel diabetic control The mechanism of chromium - insulin interaction: a door to novel diabetic control |
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Document Language |
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English |
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Abstract |
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Background of Study: The role of chromium (Cr) in maintaining normal glucose tolerance and lipid profile is well documented. However , supplementation studies gave
conflicting results, with some showing beneficial effects, and others showing a lack of response or even deterioration of measured parameters. The absence of a well
characterized function, structure, and mechanism of action of biologically active chromium has hindered the wider use of chromium in control of diabetes. Biologically
active chromium compound: Older studies proposed isolated material from yeast and porcine kidney powder , named "glucose tolerance factor". To be the biologically
active form. Chromium picolinate was later suggested. However, the most recent evidence points to an oligo peptide, low- molecular weight chromium- binding substance
(LMWCr) found mainly in the liver of mammals, detected in other tissues and isolated from urine.
Methods: Chromium- insulin interaction: Different mechanisms of interaction are suggested . The most recent one postulates that LMWCr is part of an insulin signal
amplification mechanism in which its apo-form present in cells is activated after recruiting Cr ions from blood, then binds to the insulin- receptor complex stabilizing it in
the active form by further activating the receptor kinase activity.
Results: Synthetic biologically active Cr- compounds: The use of chromium picolinate as supplement is wide spread , but questions regarding its safety exist . A new
multinuclear chromic assembly [Cr3O(O2CCH2CH3)6(H2O)3]+ or complex I was reported to mimic the action of LMWCr with no toxic effects or DNA damage.
Conclusions: The essentiality of chromium is well proven. However, without further work by different research groups to elucidate its exact role, and produce
commercially available,safe supplements, its use in treatment of diabetes remains questionable. |
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ISSN |
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1658-3175 |
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Journal Name |
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Proceedings of the 12th international congress of endocrinology |
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Volume |
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1 |
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Issue Number |
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1 |
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Publishing Year |
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2004 AH
2004 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, March 24, 2010 |
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Researchers
| سهاد باحجري | BAHIJRI, SUHAD | Researcher | Doctorate | |
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