Document Details

Document Type : Article In Journal 
Document Title :
“Alterations in the ultrastructure of the liver in chronic lead intoxication in the adult albino rat”
“Alterations in the ultrastructure of the liver in chronic lead intoxication in the adult albino rat”
 
Document Language : English 
Abstract : In the present work, the effect of chronic lead intoxication in two doses (5mg/kg body weight, as therapeutic dose and 10mg/kg body weight as sublethal dose) on the ultrastructure of the rat liver was studied. The rats were classified into three groups: one control group (10 rats), experimental group A (20 rats) who received a therapeutic dose of lead acetate orally for six months, and experimental group B (20 rats) who received a sublethal dose of lead acetate orally for six months. Ten rats of both groups A & B were sacrificed one month after the last given dose (recovery rats). Small slices of the liver of the rats of all groups were processed for electron microscopic examination. The livers of group A rats showed a few pathological changes in the form of proliferation of both rough and smooth endoplasmic reticulum, multiple areas of glycogen depletion with a few lysosomes and fat droplets. Group B rats showed marked pathological changes in both hepatocytes and Van Kuppfer’s cells. The cytoplasm of the hepatocytes showed intracytoplasmic vacuoles and a few degenerative granules. The recovery animals of group A showed good recovery, while those of group B showed only partial recovery. 
ISSN : 1658-3175 
Journal Name : Al-Azhar Medical Journal 
Volume : 2 
Issue Number : 38 
Publishing Year : 2009 AH
2009 AD 
Article Type : Article 
Added Date : Sunday, March 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
شريف حسنHassan, Sherif ResearcherDoctorate 

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