Document Details

Document Type : Article In Journal 
Document Title :
Role of magnesium sulphate in treatment of severe persistent pulmonary hypertension of the neoborn
Role of magnesium sulphate in treatment of severe persistent pulmonary hypertension of the neoborn
 
Subject : Neonatology 
Document Language : English 
Abstract : OBJECTIVE: Treatment of severe persistent pulmonary hypertension of the neoborn remains controversial and various modalities of treatment have been tried. This study was performed to evaluate the effect of magnesium sulphate (MgSO4) as a treatment of persistent pulmonary hypertension of the neoborn (PPHN) in full term babies. METHODS: This study was carried out in the Maternity and Children's Hospital, Jeddah, Kingdom of Saudi Arabia from January 1998 to 2000. A non-randomized study in 8 neoborn babies who where admitted to the Intensive Care Unit and diagnosis of PPHN based on echocardiogram was conducted to assess the efficacy of MgSO4 8% dilution in a loading dose of 200mg/kg followed by a maintenance dose of 20-100mg/kg/hour. No other vasodilators were given, patients were not hyperventilated. The aim was to keep magnesium levels 3.5-5.5mgmmol/l. RESULTS: Seven out of 8 patients showed marked improvement in partial pressure oxygen at 6 hours and maximum improvement at 24 hours. The same improvement noticed in peak inspiratory pressure, and ventilatory time support. CONCLUSION: Results suggests that MgSO4 may be considered as an alternative treatment in PPHN when no other modalities are available as it is a non aggressive and low cost treatment 
ISSN : 0379-5284 
Journal Name : The Saudi Medical Journal 
Volume : 23 
Issue Number : 10 
Publishing Year : 1423 AH
2002 AD 
Article Type : Article 
Added Date : Tuesday, March 29, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
وليد ملعاطMilaat, Waleed ResearcherDoctorate 

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