Document Details

Document Type : Article In Journal 
Document Title :
Studies on the diversity of muscarinic receptors in the autoregulation of acetylcholine release in the rodent cerebrum using furan analogs of muscarine
Studies on the diversity of muscarinic receptors in the autoregulation of acetylcholine release in the rodent cerebrum using furan analogs of muscarine
 
Subject : Pharmacology 
Document Language : English 
Abstract : Previous studies have indicated that two fccdback mechanisms, onc positive and the other negative, regulate the ratc of acctylcholinc (ACh) rclcasc.’-3 Thc positive feedback system has at least three components: a muscarinic receptor (Ms), release of substance P (SP), and influx of extracellular Ca2+. If the amount of ACh released from the presynaptic nerve terminal is low, the released ACh activates Ms, which stimulates the release of SP. Substance P increases Ca2+ influx, resulting in the release of further quantities of ACh for effective cholinergic transmission. Similarly, thrcc componcnts are present in thc ncgative feedback systcm: a presynaptic muscarinic receptor (Mi), release of methionine enkephalin (MEK), and inhibition of Ca2+ influx. If the ACh in the synaptic gap is high, it activates Mi, resulting in the release of MEK. Methionine enkephalin decreases CaZ+ influx which decreases the rate of release of ACh from the cholinergic nerve terminal. The critical first step in both of these feedback systems is activation of presynaptic muscarinic receptors, Ms and Mi. No selective agonists have been described for presynaptic muscarinic receptors. Therefore, we studied the effects of 5-methylfurfuryltrimethylammonium (5-MFT) and 5-hydrnxyfurfurltrimethylammonium (5-HMFT) on the simultaneous release of ACh, SP, and MEK from the superfused mouse cerebral slices in our search for selective agonists for Ms and Mi receptors. 5-MFT and 5-HMFT were sclcctcd for this purpose bccausc thcy have diverse effects in the peripheral nervous system 
ISSN : 0077-8923 
Journal Name : Annals of the New York Academy of Sciences 
Volume : 10 
Issue Number : 1 
Publishing Year : 1415 AH
1995 AD
 
Article Type : Article 
Added Date : Wednesday, March 30, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أسامة طيبTayeb, osama ResearcherDoctorate 

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