Document Details

Document Type : Article In Journal 
Document Title :
A comparative study of liver mixed function oxidases in camels (Camelus dromedarius), guinea pigs (Cavia porcellus) and rats (Rattus norvegicus)
A comparative study of liver mixed function oxidases in camels (Camelus dromedarius), guinea pigs (Cavia porcellus) and rats (Rattus norvegicus)
 
Subject : Pharmacology 
Document Language : English 
Abstract : 1. The activities of the drug-metabolizing enzymes, benzphetamine N-demethylase, 7-ethoxycoumarin O-deethylase and dicoumarol oxidation have been measured in vitro in the liver of camels, guinea pigs and rats. 2. In these species, levels of hepatic microsomal parameters namely microsomal protein, cytochrome P450, cytochrome b5 and NADPH-cytochrome c reductase have also been determined. 3. In general, camels seemed to have the lowest enzyme activity when compared to rats and guinea pigs. 4. Some sex differences were observed in the levels of enzymes studied. In rats and guinea pigs, males had higher benzphetamine N-demethylase than females. However, in camels and guinea pigs, females had higher 7-ethoxycoumarin O-deethylase when compared to males 
ISSN : 1532-0456 
Journal Name : Comparative Biochemistry and Physiology. Comparative Pharmacology and Toxicology 
Volume : 105 
Issue Number : 3 
Publishing Year : 1413 AH
1993 AD 
Article Type : Article 
Added Date : Wednesday, March 30, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
زهير دمنهوريDamanhouri, Zoheir InvestigatorDoctorate 
أسامة طيبTayeb, Osama ResearcherDoctorate 

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