Document Details Document Type : Article In Journal  Document Title : A serious interaction of dantrolene and theophylline A serious interaction of dantrolene and theophylline   Subject : Pharmacology  Document Language : English  Abstract : Dantrolene and theophylline have in common pronounced actions on several muscular systems. Therefore we investigated the interaction of these 2 drugs in rats. Normal cases of dantrolene (4 or 2 mg/kg) caused an increase in the lethality produced by theophylline, but without showing the expected seizures of theophylline toxicity. This may be caused by a synergistic action on the heart or blood vessels. On the other hand, a small dose of dantrolene decreased theophylline-induced seizures and death. This may be due to the effect of dantrolene on calcium release in skeletal muscles. The dosage of dantrolene should be decreased when used with theophylline  ISSN : 0145-6296  Journal Name : Veterinary and Human Toxicology  Volume : 32  Issue Number : 5  Publishing Year : 1410 AH 1990 AD  Article Type : Article  Added Date : Wednesday, March 30, 2011  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email أسامة طيب Tayeb, Osama Researcher Doctorate   Files File Name Type Description  29424.pdf pdf   Back To Researches Page