Document Details

Document Type : Article In Journal 
Document Title :
Mixed function oxidases in kidney and duodenum of camel, guinea pig and rat
Mixed function oxidases in kidney and duodenum of camel, guinea pig and rat
 
Subject : Pharmacology 
Document Language : English 
Abstract : The activities of the drug-metabolizing enzymes, aniline 4-hydroxylase, benzphetamine N-demethylase and 7-ethoxycoumarin O-deethylase have been measured in vitro in kidneys and duodenum of camels (Camelus dromedarius), guinea pigs (Cavia porcellus) and rats (Rattus norvegicus). In these species, levels of hepatic microsomal parameters namely microsomal protein, cytochrome P(450), cytochrome b(5) and NADPH-cytochrome c reductase have also been determined. In general, camels seemed to have the lowest enzyme activity when compared to rats and guinea pigs. Rats showed the highest activity in NADPH-cytochrome c reductase, aniline 4-hydroxylase and ethoxycoumarin O-deethylase among these species. However, guinea pigs showed the highest enzyme activity in cytochrome P(450), cytochrome b(5) and benzphetamine N-demethylase 
ISSN : 1532-0456 
Journal Name : Comparative Biochemistry and Physiology. Toxicology and Pharmacology 
Volume : 132 
Issue Number : 4 
Publishing Year : 1423 AH
2002 AD 
Article Type : Article 
Added Date : Thursday, March 31, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
زهير دمنهوريDamanhouri, Zoheir ResearcherDoctorate 

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