Document Details

Document Type : Article In Journal 
Document Title :
The effect of heat stress on the induced hepatic drug metabolizing system in rats
The effect of heat stress on the induced hepatic drug metabolizing system in rats
 
Subject : Pharmacology 
Document Language : English 
Abstract : The activity of the hepatic oxidative drug metabolizing system has been investigated in an experimentally-induced heat stress animal model pretreated with phenobarbitone. Female rats, unacclimatized and untrained were pretreated for 3 days with phenobarbitone as the inducing agent for the drug metabolizing systems. On the fourth day, they were restrained and exposed to an ambient temperature of 40 degrees C. One hour after acute exposures to such conditions, the activities of hepatic cytochrome P450, cytochrome b5 and NADPH cytochrome c reductase were significantly decreased in the induced animal model. Further, cytochrome P450 isozymes observed by SDS-gel electrophoresis were significantly decreased. In addition, the hypnotic effect of pentobarbitone was significantly increased. It is concluded that the activity of the hepatic oxidative drug metabolizing enzymes was decreased in induced drug metabolism systems exposed to heat stress conditions 
ISSN : 0398-7639 
Journal Name : European Journal of Drug Metabolism and Pharmacokinetics 
Volume : 27 
Issue Number : 2 
Publishing Year : 1422 AH
2002 AD 
Article Type : Article 
Added Date : Thursday, March 31, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
زهير دمنهوريDamanhouri, Zoheir ResearcherDoctorate 

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