Document Details

Document Type : Article In Journal 
Document Title :
Simultaneous onset of steroid resistant nephrotic syndrome and IDDM in two young children
Simultaneous onset of steroid resistant nephrotic syndrome and IDDM in two young children
 
Subject : Pediatric Nephrology 
Document Language : English 
Abstract : The cases are reported of two young children who developed insulin-dependent diabetes mellitus (IDDM) within 2 weeks of receiving a diagnosis of nephrotic syndrome. Neither patient responded to 8 weeks of daily prednisolone. The first patient presented at 2 years and 9 months of age. Her renal biopsy showed mesangial proliferation. The second child presented with steroid resistant nephrotic syndrome at 18 months of age and developed IDDM 2 weeks later. He achieved partial remission with cyclosporine therapy. His initial renal biopsy at 3 years of age showed minimal change disease and follow-up renal biopsy at 5 years of age showed early diabetic glomerulosclerosis. Tests for NPHS2 and WT1 genetic mutations were negative in both patients. To our knowledge this is the first report of steroid resistant nephrotic syndrome with almost simultaneous onset of IDDM in young children 
ISSN : 1757-790X 
Journal Name : BMJ Case Reports 
Volume : 9 
Issue Number : 4 
Publishing Year : 1431 AH
2010 AD 
Article Type : Case Report 
Added Date : Sunday, July 10, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جميلة قاريKari, Jameela InvestigatorDoctoratejkari@doctors.org.uk
شريف الدسوقيEl-Desoky, Sherif ResearcherDoctorate 
غدير مختارMokhtar, Ghadeer ResearcherDoctorate 
سوسن جللةJalalah, Sawsan ResearcherDoctorate 

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