Document Details Document Type : Article In Journal  Document Title : Histopathological Study of Three Leishmania Major Strains Histopathological Study of Three Leishmania Major Strains   Subject : Clinical Parasitology  Document Language : English  Abstract : Amastigotes count in inoculated foot pad and histopathologicaJ study of infected mice were performed to study three Leishmania major strains: the Senegalese strain MHOM/SN/OOIDKI(SN), the Sudanese strain MHOMlSO/89/UG8(SO), and the Saudi strain MHOMlSAl84/JISH(SA). Eight-week-old male BALB/c mice were divided into three groups. Each group was infected with one of the studied strains. Amastigotes in the inoculated foot of infected. mice in the three groups were counted at 30 and 45 days using modified fluorescence diacetate/ethidium bromide viability test, The number of amastigotes in the SA group was found to be significantly lower than that of the other two groups at both durations. There was no significant difference between the number of amastigotes in the SN and SO strains at 30 days, but it was significantly higher in the SN group than that of the SD group at 45 days post-inoculation. In the animals studied, tissue samples were obtained from the skin, liver, spleen, and testes for gross pathological changes and histopathological evaluation. The SO strain started earlier and led a more aggressive course. The SN and SA strains were less aggressive. The SA strain showed changes at an earlier time and resulted in a more aggressive course of the disease. The SN and SA strains were less aggressive. The SA strain showed the most chronic course of the three  ISSN : 1319-1004  Journal Name : Medical Science Journal  Volume : 7  Issue Number : 1  Publishing Year : 1419 AH 1999 AD  Article Type : Article  Added Date : Thursday, April 19, 2012  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email عدنان أمين Amin, Adnan Investigator Doctorate   Files File Name Type Description  32915.pdf pdf   Back To Researches Page