Document Details

Document Type : Article In Journal 
Document Title :
POLYMORPHOUS LOW-GRADE ADENOCARCINOMA VERSUS PLEOMORPHIC ADENOMA OF MINOR SALIVARY GLANDS; ULTRASTRUCTURAL FEATURES AND IMMUNOPROFILE OF GLIAL FIBRILLARY ACIDIC PROTEIN
POLYMORPHOUS LOW-GRADE ADENOCARCINOMA VERSUS PLEOMORPHIC ADENOMA OF MINOR SALIVARY GLANDS; ULTRASTRUCTURAL FEATURES AND IMMUNOPROFILE OF GLIAL FIBRILLARY ACIDIC PROTEIN
 
Document Language : English 
Abstract : Polymorphous low-grade adenocarcinoma (PLAC) and pleomorphic adenoma (PA) of minor salivary glands bear a superficial histological and immunophenotypic resemblance to each other, but can usually be separated by conventional microscopic examination. However, this is not always so. such as with PA displaying minimal or no mesenchymal components, and when only limited tissue from small biopsies is available for study. In such case. it is hard to differentiate between PLAC and PA. Five cases of PLAC and 7 cases of PA have been studied ultrastructurallv and immunohistochemically using the glial fibrillary acidic protein (GFAP) antibody. Tlie'results showed the 7 cases of PA to be moderately to strongly positive for GFAP. However, no staining for the same antibody was detected in the 5 cases of PLAC. Ultraslructural results showed that both PA and PLAC consisted of proliferated epithelial and myoepithelial cells, with the prominent presence of the later cells in PA. The results support the role for GFAP in differential diagnosis between PLAC and PA of minor salivary glands. 
ISSN : 0 
Journal Name : Alexandria Dental Journal 
Volume : 4 
Issue Number : 4 
Publishing Year : 2001 AH
2001 AD 
Article Type : Article 
Added Date : Monday, May 5, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
زينب درويشDarwish, Zeinab ResearcherDoctoratezdarweesh@kau.edu.sa

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