Document Details Document Type : Article In Journal  Document Title : Tempromandibular joint (TMJ) Tempromandibular joint (TMJ)   Document Language : English  Abstract : The purpose of this study was to evaluate as well as to compare the effect of intra-articular versus intra-peritoneal injection of dexamethasone on synovitis induced by trauma to the rat's TMJ. Twenty-seven male Wister rats were included in the present study. Induced forced condylar hypermobility achieved through opening the rat's mouth manually lO times for 10 consecutive days. Rats were randomized into three groups (3 rats in the control group, and 24 rats in both experimental groups). Group I (control group): Rats of this group were left without any treatment after induction of synovitis. Group 11: Rats were injected with a single dose of 1.2 mg/kg dexamethasone intraarticularly (after 10 days). Group Ill: Rats were injected with a single intra-peritoneal injection of 1.2 mg/kg dexamethasone (after 10 days). Control rats were sacrificed at 6 weeks, while rats in Groups 11and III were sacrificed at 1 and 6 weeks after drug injection, then joints were dissected and processed for histological study. The condylar head of the rats injected with intra-articular dexamethasone showed resorption with active osteoclastic activity, although the drug was given only once. This might be an alarming sign of the severe adverse effect(s) of the local injection of dexamethasone.  ISSN : 0  Journal Name : Int. J. Oral Maxillofacial. Surg  Volume : 34  Issue Number : 1  Publishing Year : 2004 AH 2004 AD  Article Type : Article  Added Date : Thursday, November 8, 2007  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email ابراهيم الحكيم alhakeem, ibrahim Investigator Doctorate ialhakeem@kau.edu.sa Files File Name Type Description  Tempromandibular joint.pdf pdf   Back To Researches Page