Document Details

Document Type : Article In Journal 
Document Title :
Attenuation of C-Reactive Protein Increases After Exodontia by Tramadol and Ibuprofen
Attenuation of C-Reactive Protein Increases After Exodontia by Tramadol and Ibuprofen
 
Document Language : English 
Abstract : The anti-inflammatory effects of ibuprofen and tramadol were investigated by measuring C-reactive protein concentrations after removal of an impacted lower third molar. Forty-five American Society of Anesthesiologists Class I patients were randomly categorized into 3 equal groups according to postoperative analgesic medication. The first group received tramadol (lOO mg every 8 hours), the second group received ibuprofen (400 mg every 8 hours), and the last group received half doses of both drugs in combination (50 mg tramadol every 8 hours and 200 mg ibuprofen every 8 hours). C-reactive protein was measured before surgery to exclude the presence of any preexisting inflammatory condition that might interfere with the study. C-reactive protein was also determined immediately after surgery and 72 hours postoperatively. At 72 hours, C-reactive protein had increased over postsurgery baseline by 123% in the tramadol group (P < .001), 84% in the ibuprofen group (P < .001), and only 37% in the combined analgesic group (P = .078). These results suggest that tramadol may produce supra-additive anti-inflammatory effects with ibuprofen after third-molar extractions. 
ISSN : 0 
Journal Name : the american dental society of anesthesiology 
Volume : 53 
Issue Number : 1 
Publishing Year : 2006 AH
2006 AD 
Article Type : Article 
Added Date : Thursday, December 6, 2007 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ابراهيم الحكيمAl-hakim, ibrahim InvestigatorDoctorateialhakeem@kau.edu.sa

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