Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project مكونات الهواء تؤثر على تكوين الثرومبين في الناس الأصحاء. مشروع RAPTES |
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Subject |
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Enviromental sciences |
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Document Language |
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English |
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Abstract |
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ABSTRACT
Objectives Increases in ambient particulate matter
(PM) have been associated with an elevated risk of
stroke, myocardial ischaemia and coronary heart disease,
with activation of blood coagulation likely playing an
important role. PM-mediated activation of two major
activation pathways of coagulation provides a potential
mechanism for the observed association between PM
and cardiovascular disease. However, it remains unclear
which specific characteristics and components of air
pollution are responsible.
Methods In order to investigate those characteristics
and components, we semiexperimentally exposed healthy
adult volunteers at five different locations with increased
contrasts and reduced correlations among PM
characteristics. Volunteers were exposed for 5 h,
exercising intermittently, 3–7 times at different sites from
March to October 2009. On site, we measured PM mass
and number concentration, its oxidative potential (OP),
content of elemental/organic carbon, trace metals,
sulphate, nitrate and gaseous pollutants (ozone, nitrogen
oxides). Before and 2 and 18 h after exposure we
sampled blood from the participants and measured
thrombin generation using the calibrated automated
thrombogram.
Results We found that thrombin generation increases
in the intrinsic (FXII-mediated) blood coagulation
pathway in relation to ambient air pollution exposure.
The associations with NO2, nitrate and sulphate were
consistent and robust, insensitive to adjustment for other
pollutants. The associations with tissue factor-mediated
thrombogenicity were not very consistent.
Conclusions Ex vivo thrombin generation was
associated with exposure to NO2, nitrate and sulphate,
but not PM mass, PM OP or other measured air
pollutants. |
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ISSN |
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1351-0711 |
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Journal Name |
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OCCUPATIONAL AND ENVIRONMENTAL MEDICINE |
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Volume |
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70 |
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Issue Number |
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5 |
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Publishing Year |
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1434 AH
2013 AD |
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Article Type |
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Article |
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Added Date |
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Tuesday, June 4, 2013 |
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Researchers
| Maciej Strak | Strak, Maciej | Researcher | | |
| Gerard Hoek | Hoek, Gerard | Researcher | | |
| Maaike Steenhof | Steenhof, Maaike | Researcher | | |
| Evren Kilinc | Kilinc, Evren | Researcher | | |
| Krystal J. Godri | Godri, Krystal J. | Researcher | | |
| Ilse Gosens | Gosens, Ilse | Researcher | | |
| Ian S Mudway | Mudway, Ian S | Researcher | | |
| Rene van Oerle | van Oerle, Rene | Researcher | | |
| Henri M. H Spronk | Spronk, Henri M. H | Researcher | | |
| Flemming R Cassee | Cassee, Flemming R | Researcher | | |
| Frank J Kelly | Kelly, Frank J | Researcher | | |
| Roy M Harrison | Harrison, Roy M | Researcher | | |
| Bert Brunekreef | Brunekreef, Bert | Researcher | | |
| Erik Lebret | Lebret, Erik | Researcher | | |
| Nicole A. H Janssen | Janssen, Nicole A. H | Researcher | | nicole.janssen@rivm.nl |
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