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Document Type |
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Thesis |
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Document Title |
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The Effect of Coenzyme Q10 and Caffeine on Induced Parkinson-Like Disease in Rats تأثير مرافق الانزيم Q10 والكافيين على مرض شبيه باركينسون المستحث في الجرذان |
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Subject |
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Biochemistry department |
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Document Language |
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Arabic |
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Abstract |
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Parkinson's disease (PD) is a progressive neurological disorder associated with selective degeneration of nigrostriatal dopaminergic neurons. It is the most common of the neurodegenerative movement disorders, affecting approximately 1% of the population over age 65. Though the exact cause of the neurodegeneration is unknown, it has been shown that environmental factors can contribute to the onset of Parkinson's disease. Parkinsonian symptoms are seen following exposure to the herbicide paraquat (PQ), and the fungicide maneb (MB). Recent epidemiological studies have established an association between caffeine and coenzyme Q10 and a reduced risk of developing PD. The aim of the present study was to throw the light on the role of coenzyme Q10 (CoQ10) with caffeine in an experimental model of parkinsonism induced by PQ and MB in rats. Sixty eight adult male Wistar rats were divided into 5 groups; group one received saline, group two received PQ and MB, group three was subdivided into 3 subgroups and received PQ and MB twice a week for 6 weeks and different doses of caffeine ( 20, 40, 80 mg/kg ) daily, group four was subdivided into 3 subgroups and received PQ and MB twice a week for 6 weeks and different doses of CoQ10 ( 25, 50, 100 mg/kg ) daily and group five was subdivided into 9 subgroups and received PQ and MB twice a week for 6 weeks and different doses of CoQ10 ( 25, 50, 100 mg/kg ) and caffeine ( 20, 40, 80 mg/kg ) daily. The results showed that treated groups showed behavioural improvement comparing to PQ and MB group and dopamine analysis showed normal level of dopamine. These results provide further evidence that CoQ10 and Caffeine can protect against Parkinson’s disease. Furthermore, they show that combinations can produce additive neuroprotective effects. |
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Supervisor |
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Prof. Khalid Abulnaja |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1432 AH
2011 AD |
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Co-Supervisor |
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Prof. Mansour Sulaiman |
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Added Date |
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Wednesday, October 26, 2011 |
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Researchers
| ليلى طاهر تونسي | Toonisi, Laila Tahir | Researcher | Master | |
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