Document Details

Document Type : Thesis 
Document Title :
Association of serum apelin concentrations with colon cancer risks in Saudi patients
علاقة تراكيز مصل الأبلين و خطورة الاصابه بسرطان القولون لدى مرضى سعوديين
 
Subject : Biochemistry department 
Document Language : Arabic 
Abstract : Apelin, a protein secreted by the adipose tissue and other organs, has a broad array of physiological roles in the human body including angiogenesis. This study is, to our knowledge, the first to report an association between serum apelin concentrations and colon cancer risk. We evaluated the relationship between serum apelin level and colon cancer risk in representative samples of Saudi females and males. In our case-control study, individuals with colon cancer (n=59; age 53.8 ± 11.8 yr; BMI 25.97±5.8 kg/m2) and colonoscopy-negative controls (n=60; age 47.40±14.1 yr; BMI 28.84±6.3 kg/m2) were recruited from King Abdulaziz hospital and Oncology Center (Jeddah) from 2009 to 2011. Serum apelin levels were measured by ELISA technique. Here, we report that serum apelin concentrations in humans exhibit a sexual dimorphism. In the patient group, we observed a significant increased apelin level in the obese males than the non-obese males (P=0.01) and the obese females (P=0.004). On the other hand, the obese and non-obese female patients showed a significant (P=0.04) decrease in apelin level in compation to the obese and non-obese female controls. Regarding the colon cancer stages, the analysis showed an inverse correlation between serum apelin levels and the stages in obese males (r= - 0.673, P= 0.05). In conclusion, serum apelin levels are likely to be associated with increased colon cancer risk in Saudi obese males. 
Supervisor : Dr. Roydah N. alharithy 
Thesis Type : Master Thesis 
Publishing Year : 1433 AH
2012 AD 
Added Date : Tuesday, July 10, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
وعد عائض العتيبيAl-Otaibi, Waad AyedResearcherMaster 

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