Document Details
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Document Type |
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Thesis |
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Document Title |
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Relationship between bone mass, inflammatory markers and cardiovascular disease in postmenopausal women العلاقة مابين كثافة العظام ومؤشرات الالتهاب العام و امراض القلب الوعائية لدى السيدات في مرحلة مابعد انقطاع الطمث |
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Subject |
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Faculty of Medicine > Medical BIOCHEMISTRY |
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Document Language |
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Arabic |
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Abstract |
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Osteoporosis and cardiovascular disease are both very common age-related disorders in postmenopausal women and are associated with high morbidity and mortality. Both conditions are often seen in the same individual. These conditions progress silently until a fracture or myocardial infarction occurs. Prevalence rates of osteoporosis and cardiovascular diseases (CVD) are expected to rise globally along with the rapid economic development and urbanization. It seems that these two conditions may be sustained by similar or common patho-physiological mechanisms and risk factors. The role of inflammation acting in parallel on vascular and bone tissue is well documented.
The study hypothesis is that reduced bone mass and increased serum concentrations of inflammatory markers are related to the number and/or the degree of occluded coronary arteries among postmenopausal females.
The aim of this study is to evaluate the relationship between atherosclerotic disease and bone mass in group of postmenopausal females with detectable atherosclerotic plaques involving one or more vessels.
One hundred and seventy seven postmenopausal female patients undergoing routine coronary angiography were randomly recruited from the catheterization unit of the department of internal medicine at King Abdulaziz University Hospital in a cross-sectional study design over the period of 11 months (May 2011 – April 2012). They were categorized into 3 subgroups according to the number of stenosed coronary arteries into: zero vessel disease (n=87), single and double vessel disease (n=44) and multi-vessel disease (n=46). After obtaining informed consent, suitable women were interviewed using a questionnaire regarding socio-demographic characteristics, health history, lifestyle habits and dietary intakes. Fasting blood samples were collected and processed for estimation of fasting lipid profile, fasting glucose and insulin levels, high sensitivity-C reactive protein (hs-CRP), liver enzymes, creatinine, calcium, phosphate, osteocalcin, bone specific alkaline phosphatase (ALP), albumin, intact parathyroid hormone (PTH), and 25(OH) vitamin D. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. BMD values were classified according to the world health organization criteria; osteopenia was defined at a T-score between -1 and -2.5 standard deviation below the mean, while a T-score equal to or below than -2.5 standard deviation below the mean reflected osteoporosis and a T-score equal to or above -1 standard deviation above the mean was considered normal.
Low BMD was associated with increased classical risk factors for CVD and osteoporosis in postmenopausal women. Increased prevalence rate of osteopenia and osteoporosis with the increase in the number of occluded coronary arteries was observed in our study sample of postmenopausal women. High percentage of osteopenia and osteoporosis in all subgroups was found among subjects with serum hypovitaminois D. Low levels of osteocalcin and increased insulin resistance were also associated with increased cardiovascular risk in postmenopausal women. Serum levels of CRP were positively correlated with BMD values and negatively correlated with serum osteocalcin levels. High dietary fat, fatty acid and cholesterol intakes were associated with increased coronary risk and decreased dietary intakes of vitamin D and calcium were found to affect both of bone and cardiovascular health.
The overall results of this study showed that most of the modifiable risk factors of both chronic conditions are leading to an increased rate of bone loss in our study population of postmenopausal women. However, this study has a cross-sectional design, and no long-term longitudinal follow up data are available. Association between low bone mineral density and coronary artery calcification in postmenopausal women with osteopenia-osteoporosis: cross-sectional study. |
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Supervisor |
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Dr. Eman Mokbel Alissa |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1435 AH
2014 AD |
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Added Date |
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Sunday, May 18, 2014 |
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Researchers
| وفاء عبد الله النهدي | ALNAHDI, WAFA ABDULLAH | Researcher | Master | |
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