Document Details

Document Type : Thesis 
Document Title :
The Association of Serum Chemerin Level with Risk of Subclinical Atherosclerosis in Saudi Patients
علاقة معدل الكيميرين في الدم بخطر الاصابة المبكرة لتصلب الشرايين في المرضى السعوديين
 
Subject : Faculty of Medicine > Medical BIOCHEMISTRY 
Document Language : Arabic 
Abstract : Background and aim: Atherosclerosis is a silent killer disease and it will continue to be a major health problem because of high prevalence of noncommunicable diseases including diabetes, obesity and hypertension. Chemerin is a novel adipokine that has been suggested to play a link between obesity, inflammation and atherosclerosis. Its concentration are elevated in obese and inflammatory state. However, it remains unclear whether chemerin is involved in patients with cardiovascular diseases. The aim of the study is to investigate serum chemerin levels in patients with subclinical atherosclerosis and their matched controls, to explore the possible correlations between chemerin and other cardiovascular risk factors like obesity, and atherosclerosis, to assess the relation of chemerin level as a potential novel marker of subclinical atherosclerosis as defined by carotid intima-media thickness (CIMT) and to investigate whether dietary intake are associated with cardiovascular risk. Methods: A total of 200 patients who underwent carotid doppler ultrasound were randomly selected from King Abdulaziz University Hospital in Jeddah, Saudi Arabia. Data of demographic characteristics, medical history and life style habits included diet, physical activity and smoking were collected through structured questionnaire. Anthropometric measurements and biochemical variables were estimated for all study subjects. Results: Chemerin levels were slightly higher in subclinical atherosclerotic group with body mass index (BMI)≥ 30 kg/m2 compared with those with a BMI <25 kg/m2. Chemerin has positive correlation with age and C-reactive protein and negative correlation with high density lipoprotein-cholesterol. Percentages of energy derived from carbohydrate, fat and monounsaturated fat were significantly associated with atherosclerosis. Conclusion: Chemerin level may play a pivotal role in obesity and inflammation. However, further studies are needed to clarify the exact role of serum chemerin level in development and progression atherosclerotic diseases. 
Supervisor : Dr. Eman Alissa 
Thesis Type : Master Thesis 
Publishing Year : 1437 AH
2016 AD 
Co-Supervisor : Prof. Adel Abdulrafee / Dr. Nabeel Al-ama. 
Added Date : Wednesday, January 27, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سارا رفعت حلميHelmi, Sara RifaatResearcherMaster 

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