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Document Type |
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Thesis |
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Document Title |
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Effect of grape seeds extract on hyperlipidemic male adult rats تأثير مستخلص بذور العنب على الجرذان المصابة بارتفاع دهون الدم |
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Subject |
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Faculty of Home Economics > Food and Nutrition |
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Document Language |
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Arabic |
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Abstract |
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Objective: The present study was carried out to investigate the effects of oral administration of grape seeds extract at three dosage levels (200, 400 and 600 mg/kg b. wt.) to hyperlipidemic rats for 30 days on body weight gain %, feed efficiency ratio, relative weights liver, serum levels of total cholesterol (TC), triglycerides (TG), lipoprotein fractions and liver enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were performed. Antioxidant enzymes, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx,) were determined in homogenate liver. Histopathological examination of liver was also carried out.
Methods: Fourty male Wistar rats were divided into five equal groups as follows: group1: negative control group, group 2: positive control (hyperlipidemic rats) groups 3,4 and 5 (hyperlipidemic) orally given grape seeds extract in doses of 200, 400 and 600 mg/kg b.wt., respectively.
Results: The results showed that oral administration of grape seeds extract to hyperlipidemic rats for 30 days significantly decreased serum levels of TC, TG, low density lipoproteins cholesterol (LDL-c), very low density lipoproteins cholesterol (VLDL-c) and elevated serum levels of liver enzymes (AST and ALT) when compared to the control positive group. Levels of high density lipoprotein cholesterol (HDL-c) and antioxidant enzymes were significantly increased as compared to the control positive group. Histopathological examination of liver sections of rats fed on grape seeds extract treated groups showed alleviation of histological degeneration changes caused by high level of cholesterol in the positive control group.
Conclusion: The results indicated that grape seeds extract produced potent antiatherogenic and antioxidant effects in Hyperlipidemic rats. This study recommends that oral administration of grape seeds extract may be beneficial for patients who suffer from hypercholesterolemia or hyperlipidemic. |
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Supervisor |
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dr.Amani Alawi Al-Rasheedi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1437 AH
2016 AD |
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Added Date |
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Monday, June 6, 2016 |
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Researchers
| منيرة منصور منصور | Mansour, Munirh Mansour | Researcher | Master | |
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