Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
Effect of fenugreek seeds against irradiation-induced oxidative stress in male adult rats تأثير بذور الحلبة ضد الإجهاد التأكسدي الناتج عن تعريض ذكور الجرذان البالغة للإشعاع |
|
Subject |
: |
Faculty of Home Economics > Food and Nutrition |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
Objective: The present study aimed to evaluate the protective effect of fenugreek seeds 5% before and after 14 days on rats' exposure to whole body irradiation 6.5 Gy. Body weight gain%, feed efficiency ratio and relative weight of liver and spleen, complete blood count, serum level of total thiols, liver function, endogenous antioxidant status and lipid peroxidation were determined as well, histopathological examination of liver and spleen were also performed. Methods: Forty-two healthy adult male Wister rats were divided into four groups: normal control, irradiated control, pre-treated irradiated group and pre and post-treated irradiated group. Results: The results showed that feeding rats on diet supplemented with fenugreek seeds at concentration 5% before and after 14 days of irradiation exposure significantly improved biological evaluation, complete blood count, total thiols level. Moreover, increased the reduced glutathione (GSH) content and superoxide dismutase (SOD) activity accompanied with exhibited elevated liver enzymes (AST, ALT and ALP) and lipid peroxidation, weight loss as compared with irradiated control group. Histopathological investigation of liver and spleen tissues of irradiated rats represented the presence of sever changes, meanwhile treatment overcome this changes, the majority of the cells tend to be normal, this improvement in the cells may explain the radioprotective effect of the fenugreek seeds under study. Conclusion: This study showed that fenugreek seeds have significantly-attenuated radiation induced oxidative stress in liver. Therefore, it recommends to use fenugreek seeds to alleviate the oxidative stress caused by irradiation in Wister rats.
Key words: Fenugreek seeds, total thiols, radiation, rats, radioprotective, antioxidant, histopathology. |
|
Supervisor |
: |
Dr. Amani Al-Rasheedi |
|
Thesis Type |
: |
Master Thesis |
|
Publishing Year |
: |
1437 AH
2016 AD |
|
Added Date |
: |
Tuesday, June 7, 2016 |
|
Researchers
| سارة مسفر العري | Al-amri, Sarah Mesfer | Researcher | Master | |
|
Back To Researches Page
|