Document Details
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Document Type |
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Thesis |
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Document Title |
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Effect of Wheat Germ Oil on Oxidative Stress in Male Rats تأثير زيت جنين القمح على الإجهاد التأكسدي في ذكور الجرذان |
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Subject |
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Faculty of Home Economics > Food and Nutrition |
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Document Language |
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Arabic |
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Abstract |
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Objective: The present study was carried out to investigate the effect of oral administration of wheat germ oil at three dosage levels (150, 300 and 450 mg/kg.b.wt.) to male rats intoxicated with potassium bromate (KBrO3) after 4 weeks of treatment on body weight gain%, feed efficiency ratio and relative weights of liver and kidneys, blood urea nitrogen (BUN), uric acid (UA), creatinine (Cr), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and oxidative stress markers such as glutathione (GSH), malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) were determined. Histopathological examination of liver was also performed.
Methods: Forty adult male Wistar rats were divided into five equal groups as follows: group1: negative control group, group 2: positive control group, groups 3, 4 and 5 intoxicated with KBrO3 and orally given wheat germ oil at dosage levels 150, 300 and 450 mg/kg.b.wt., respectively.
Results: The results showed that oral administration of wheat germ oil at three dosage levels (150, 300 and 450 mg/kg.b.wt.) to intoxicated rats with potassium bromate for 4 weeks significantly increased feed intake (FI), feed efficiency ratio (EFR), body weight gain percent (BWG%), and decreased relative liver weight, serum levels of blood urea nitrogen (BUN), creatinine (Cr), and liver enzymes (AST, ALT and ALP) in a dose depended manner when compared to the control positive group. Oxidative stress markers (MDA, GSH, GPx, SOD and CAT) were significantly improved as compared to the control positive group. Histopathological examination of liver sections of rats orally given wheat germ oil showed alleviation of histological degeneration changes caused by KBrO3.
Conclusion: The results suggest that oral administration of wheat germ oil induce potent hepatoprotective, nephroprotective and antioxidant effects in rats intoxicated by KBrO3. This study recommends that, intake of wheat germ oil may be beneficial for patients with oxidative stress which is linked as a main cause of many diseases.
Key words: Wheat germ oil, Antioxidant enzymes, Oxidative stress, Potassium bromate. |
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Supervisor |
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Dr. Reham Abo elmahasen Arafat |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1437 AH
2016 AD |
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Added Date |
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Wednesday, June 8, 2016 |
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Researchers
| اسمهان طاهر الاهدل | Alahdal, Asmahan Taher | Researcher | Master | |
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