Document Details

Document Type : Thesis 
Document Title :
Protective Effect of Ginger and Cinnamon Aqueous Extracts Against Aspirin-Induced Peptic Ulcer
التأثير الوقائي للمستخلص المائي للجنزبيل و القرفة ضد الاسبرين المسبب لقرحة المعدة
 
Subject : Faculty of Home Economics > Food and Nutrition 
Document Language : Arabic 
Abstract : Objective: The present study was carried out to investigate the gastro-protective effect of aqueous extracts of ginger, cinnamon and their combination, on gastric acid secretion and healing of acute gastric ulcer induced by aspirin in male rats in doses of 100 and 200 mg/kg After 2 weeks of prevention on oxidative stress markers and biomarkers of gastric ulcer (gastric ulcer index, gastric juice acidity, gastric juice volume). As well as histopathological examination of stomach was also performed. Methods: Fifty six adult male Wister rats were divided into seven equal groups as follows: group 1: negative control group, group 2: positive control group, groups 3, 4, 5 and 6: were orally given ginger and cinnamon aqueous extracts in doses of 100 and 200 mg/kg b.wt, respectively, Group 7: orally given the combination of ginger and cinnamon in a dose of 200 mg/kg b.wt. At the end of the experimental period all groups were given aspirin 200 mg/Kg b.wt., to induce peptic ulcer except group 1. Results: The results showed that oral administration of ginger, cinnamon aqueous extracts and their combination for 2 weeks significantly improved gastric juice volume, decreased the gastric juice acidity and gastric ulcer index in depended manner, Oxidative stress markers were significantly improved as compared to the control positive group. Histopathological examination of the stomach showed alleviation of histological degeneration changes caused by aspirin. Conclusion: The results suggest that oral administration of ginger and cinnamon aqueous extracts and their combination may be useful in the management of gastric ulcer. The study recommends that, intake of ginger and cinnamon aqueous extracts and their combination may be beneficial for patients suffering from acute gastric ulcer. Key words: Peptic Ulcer _Ginger _Cinnamon_ Ant oxidation Enzymes. 
Supervisor : Dr. Reham Abo El mahasen Arafat 
Thesis Type : Master Thesis 
Publishing Year : 1437 AH
2016 AD 
Co-Supervisor : Dr. Heba Abbas Sindi 
Added Date : Wednesday, June 8, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
رحيق عبد المجيد محمد باصبرينBasbrin, Raheeq Abd-Almajeed MohammeResearcherMaster 

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