Document Details
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Document Type |
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Thesis |
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Document Title |
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The Prevalence of Rh Phenotypes and the Distribution of the Major Rh Antigens (D, C, E, c and e) among Saudi Blood Donors in Aseer Region معدل انتشار المستضدات السطحية لعامل ريسوس للمتبرعين السعوديين بالدم في منطقة عسير |
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Subject |
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Faculty of Applied Medical Sciences |
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Document Language |
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Arabic |
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Abstract |
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The Rh system is the most significant blood group system after ABO in the field of transfusion medicine, and the primary cause of the hemolytic disease of fetal and newborns. In addition, Rh antibodies are the most prevalent RBCs alloantibodies among multitransfused patients in Saudi Arabia and other parts of the world. Several studies showed that the distribution of the Rhesus antigens varies from one population to another. Therefore, due to lack of relevant studies among Saudi donors, the aim of this research was to determine the frequencies of Rh phenotypes and the distribution of the major Rhesus antigens (D, C, E, c, e) among Saudi blood donors in Aseer region. The present findings will provide a reference for the frequencies of Rh antigens and phenotypes among Saudi population, instead of relying on international published ratios for other ethnic groups, which may help to avoid Rh-mediated DHTR in previously alloimmunized patients. This research conducted in the blood bank of Aseer central hospital on 734 healthy Saudi male donors, done by the antigen-antibody agglutination test using a fully automated Blood Bank analyzer TANGO™ optimo. The results showed the distribution of the major Rh antigens in the study sample as D (91.7%), C (74.1%), E (22.8%), c (74.4%) and e (97.3%) and eight Rh phenotypes were reported as DCcee (35.3%) was the most common phenotype followed by: DCCee (25.9%), DCcEe (12.6%), ccee (7.8), Dccee (7.8%), DccEe (7.5%), DccEE (2.6%) and Ccee (0.5%). The present research concludes that the frequencies of Rh antigens and Rh phenotypes displayed broad variance among Saudi blood donors and other ethnic groups. It is recommended to conduct further studies in different regions of Saudi Arabia, in order to examine geographical and regional variance in Rh antigens and Rh phenotypes frequencies. |
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Supervisor |
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Dr. Mohammed Hassan Saiem Al Dahr |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1438 AH
2017 AD |
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Added Date |
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Monday, February 13, 2017 |
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Researchers
| علي سعيد عسيري | Aseeri, Ali Saeed | Researcher | Master | |
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