Document Details

Document Type : Thesis 
Document Title :
Decreased FT3 Levels in Dialysis Patients as a Possible Indicator for Poor Prognosis in Post Kidney Transplant Patients
انخفاض في مستوى الهرمون الدرقي االحر (FT3) لمرضى الغسيل الكلوي يعتبر كمؤشر لعدم التجاوب بعد عملية زراعة الكلى
 
Subject : Faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : Background: The prevalence of end stage Chronic Kidney Disease (CKD) in Saudi Arabia increased over the last 3 decades. This increase cause a huge burden on hospitals resources in the country. As because kidneys play an important role in the synthesis, metabolism and secretion of hormones, the impairment of kidney function leads to disturbed thyroid physiology and functions in various ways. FT3 is a marker of comorbidity in end stage renal disease patients and most of these patients have reduced level of FT3, reflecting reduced conversion of T4 to T3 in the peripheral tissue. Aim: This study aimed to analyze and measure the level of thyroid hormones for dialysis patients in Saudi population. Method: A total 137 serum samples were collected from hemodialysis patients and the control group included 137 healthy participants. The samples were collected during routine work in the Clinical Chemistry Laboratories at King Fahed Armed Forces Hospital (Jeddah). The blood samples were taken for standard laboratory analysis, Detection of renal function test was performed on all samples to determine the level of Na, K, Urea and creatinine. Also, detection of thyroid dysfunction was performed to detect the level of TSH, FT4 and FT3. Results: Our study detected that, severity of renal dysfunction was associated with a significant reduction in serum FT3 levels and a decrease in serum FT4 whereas TSH levels were not significantly altered in renal hemodialysis patients. The significant reduction in FT3 was found in 38% renal patients (P=0.0001), and low FT4 was found in 40.1% renal patients (P=0.0001). Conclusion: Due to the association between decreased FT3 level and increased mortality and failure of kidney transplantation, it is important to monitor FT3 level periodically to improve the success rate of kidney transplantation. 
Supervisor : Dr. Adil Glazer Ahmed Choudry 
Thesis Type : Master Thesis 
Publishing Year : 1438 AH
2017 AD 
Added Date : Monday, March 27, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
رشا أحمد يغمورYaghmour, Rasha AhmedResearcherMaster 

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