Document Details

Document Type : Thesis 
Document Title :
CORRELATION OF CRP AND HYPOALBUMINEMIA WITH MORBID OBESITY - RETROSPECTIVE STUDY IN KAU HOSPITAL, JEDDAH, SAUDI ARABIA
إرتباط البروتين التفاعلي C ونقص ألبيومين الدم مع البدانة المفرطة - دراسة استيعادية بمستشفى جامعة الملك عبدالعزيز، جدة، المملكة العربية السعودية
 
Subject : Faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : Background: Obesity is a chronic low-grade inflammation state which lead to increase in C-Reactive Protein (CRP) and many nutrient deficiencies such as Serum albumin (SA). Bariatric surgery is accepted nowadays as the most effective tool in the treatment and control of morbid obesity. Low SA has been shown to correlate with risk for surgical complications and mortality. Aim: To assess the correlation between obese patients, hypoalbuminaemia and CRP. Methods: The medical record of 165 patients who suffers from obesity and were advised to undergo bariatric surgery at King Abbdulaziz University hospital (KAUH) during 2010 until 2017 were examined. CRP and SA were measured using standard methods. Result: 165 patients were studied. There were 44 males (26.66%) and 121 were females (73.33%) with a mean age of 38 years (range 18-62). 50 patients (30.30% of all patients and 32.26% of patients who had pre-operative albumin assessment) had hypoalbuminemia and 105 patients (63.63% of all patients and 67.74 % of patients who had pre-operative albumin assessment) had normal albumin level. 27 patients (16.36% of all patients and 78.1% of patients who had pre-operative CRP assessment) had high CRP and 4 patients (2.42% of all patients and 12.9% of patients who had pre-operative CRP assessment)) had normal CRP. There was no significant correlation between BMI and CRP but BMI was significantly lower in patients who have normal CRP level compared with those who have high CRP level. There was a trend for a negative correlation between CRP and albumin (r = -0.300, p = 0.10). BMI is significantly negatively correlated with albumin level (r = -0.219, p < 0.02). Albumin level is significantly negatively correlated with age. CRP level is strongly significantly positively correlated with lymphocytes percentage (r =0.826, p <0.02). We recommend carrying more in vitro and in vivo studies to clarify the pathophysiology of serum albumin level derangements in inflammation and obesity. Studies are also needed to identify any association between preoperative CRP and albumin levels with patient surgical outcomes. 
Supervisor : Dr. Noura Eid 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Co-Supervisor : Dr. Abdulmalik Altaf 
Added Date : Thursday, February 8, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سمية حسان راضيRadi, Sumaia HassanResearcherMaster 

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