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Document Type |
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Thesis |
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Document Title |
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STUDY OF SOME INFLAMMATORY MEDIATORS IN SERUM OF PATIENTS WITH ATHEROSCLEROSIS AND ACUTE MYOCARDIAL INFRACTION دراسة لبعض دلالات الالتهاب في مصل الدم لمرضى تصلب الشرايين و احتشاء عضلة القلب الحاد( الجلطة القلبية الحادة) |
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Subject |
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Faculty of Medicine |
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Document Language |
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Arabic |
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Abstract |
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Atherosclerosis, is a progressive disease characterized by lipids and fibrous elements accumulation in the arteries which leads to thrombus formation. It is a lesion made of three compartments, the first is cellular composed of smooth muscle cells and macrophages, the second compartment is connective tissue and extracellular lipids and the third compartment is intracellular lipids that is found within the macrophages. Atherosclerosis is developed as an inflammatory stimuli, subsequent with many cytokines and release of inflammatory markers.
Serum amyloid A (SAA) and Resistin are inflammatory acute protein known to be released during atherosclerosis. Also, Adiponectin is known to have an anti-inflammatory, anti-atherogenic properties. The aim of the study was to determine the level of inflammatory mediators SAA, resistin and adiponectin in serum of patients with stable angina and those with acute myocardial infarction and to correlate the level of SAA and resistin with troponin-T and CK-MB level.
Materials and methods:
This study was carried on 20 normal individuals as a control group, 20 patients with stable angina and 20 patients with acute myocaridal infarction. All the participants in the study were males with age ranging from 40-68 years. The estimation were done on freshly prepared serum immediately or on serum samples stored at -20°c. Repeated freezing , thawing of the samples were avoided. SAA, Resistin and adiponectin levels were quantitatively measured by enzyme linked immunosorbent assay ( ELISA ).
Results:
The level of SAA and resistin were significantly higher in in both stable angina and AMI group as compared to the control group. The level of adiponectin was insignificantly lower in the stable angina group, but was significantly lower in the AMI group, as compared to the control group. There was a positive correlation between SAA, resistin , troponin-T and CK-MB in both patients groups.
Conclusion:
From the present study we have concluded that SAA can be used as a confirmatory marker for stable angina, and a diagnostic tool for AMI patients.
Also, we found that the levels of resistin in stable angina and in acute myocardial infarction groups was significantly higher . So, resistin may play a role as a diagnostic biomarker for both groups.
For adiponectin we have concluded that it has the antiatherogenic property and it’s level was insignificantly lower in stable angina and significantly lower in acute myocardial infarction groups. It has a negative correlation to both Resistin and SAA.
Moreover, both SAA and resistin have a positive correlation with troponin-T as well as CK-MB, which indicates that the patient has or will have the atherosclerotic plaque for |
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Supervisor |
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Prof.Zainy Mohammed Banjar |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Added Date |
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Wednesday, February 14, 2018 |
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Researchers
| عهود طلعت متولي | MOTWALLI, OHOUD TALAT | Researcher | Master | |
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