Document Details

Document Type : Thesis 
Document Title :
تقدير احتمالية الارتباط بين مستويات مضادات الأكسدة وتعدد أنماط المورث APOE لدى المرضى السعوديين المصابين بالعته
تقدير احتمالية الارتباط بين مستويات مضادات الأكسدة وتعدد أنماط المورث APOE لدى المرضى السعوديين المصابين بالعته
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : Dementia is a neurocognitive disorder that characterized by progressive loss of mental functions that interferes with an individual’s daily life. There are many risk factors involve in dementia pathogenesis. For example, oxidative imbalance and a presence of E4 allele of APOE gene which is known as strongest genetic risk factor linked to Alzheimer disease. An association between APOE polymorphism and oxidative stress has not been clarified. The purpose of this study is to determine the possible associations between antioxidant serum marker and apolipoprotein E (APOE) genotypes in an elderly demented Saudi population. Eighty subjects were included in this study and classified according to cognitive function as two groups, control (n=40) and demented patients (n=40). Blood samples were collected, antioxidant capacity (FRAP) and lipid peroxidation (MDA) were measured. APOE genotypes were determined using restriction enzyme analysis. The result shows that serum antioxidant level was significantly reduced in patients compared to control (p-value= 0.0125< 0.05). Also, lipid peroxidation level was significantly higher in patient compared to control (p-value=0.0167˂0.05). For APOE, three alleles (E2, E3 and E4) and four genotypes (E2/3, E3/3, E3/4 and E4/4) were identified. There was a significant difference between alleles and genotypes distribution among patients and control as the frequency of E4 was higher in dementia patients (p-value=0.0168 and 0.0447˂0.05), respectively. However, there were no significant association between APOE status and serum levels of (FRAP) or (MDA). In conclusion, there was no correlation between lower level of antioxidant capacity or higher level of lipid peroxidation and APOE4 polymorphisms. They are independent risk factors for dementia in Saudi patients. 
Supervisor : Prof. Taha Abdullah Kumosani 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Co-Supervisor : Dr. Etimad Abbas Huwait 
Added Date : Tuesday, February 27, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عهود عبد العزيز العمريAlomari, Ohoud AbdulazizResearcherMaster 

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