Document Details
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Document Type |
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Thesis |
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Document Title |
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THE PREVALENCE OF ATYPICAL ANTIBODIES AMONG SICKLE CELL ANEMIA PATIENTS AT ARMED FORCES HOSPITAL IN THE SOUTHERN REGION معدل انتشار الأجسام المضادة الشاذة في مرضى الأنيميا المنجلية لبمستشفى القوات المسلحة بالمنطقة الجنوبية |
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Subject |
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Faculty of Applied Medical Sciences |
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Document Language |
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Arabic |
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Abstract |
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Sickle Cell Anemia (SCA) or homozygous sickle cell disease (Hb SS) is an inherited blood disorder that results from a point mutation in the β-globin polypeptide chain of the hemoglobin molecule in which glutamic acid is substituted by Valine. Clinically, the disease is characterized by period of wellness (steady stable) and periods of crises often brought about by chronic hemolytic anemia, vaso-occlusion, splenic sequestration or aplasia organ complications may occur. The severity of crises ranges from mild to severe.
Blood transfusion is crucially essential in the management of SCA. Paradoxically, repeated blood transfusion induces alloimmunization (atypical antibodies) in SCA, making transfusion support more difficult, if not impossible, to provides safely to the patient. Knowledge of the rates and patterns of atypical antibodies profile of the SCA population may mitigate this problem. Regrettably, these rates and patterns have rarely been studied in the SCA population of the Southern region of the Kingdom of Saudi Arambia (KSA). The aim of this study was to determine the prevalence of RBC alloimmunization and the identification of atypical antibodies among SCA patients admitted for blood transfusion at the Armed Forces Hospitals South Region (AFHSR) over a period of two years from January 2015 to January 2017. The study population was made up of the hospital's electronic medical record, code D57.0, which restricts sickle cell patients to crises and steady stable. This study is the First of AFHSR.
Patient diagnosis for SCD was confirmed by Hb electrophoresis technique. The clinical transfusion records of target patients were analyzed for blood group, age, gender, antibody specificity, age at first incidence of alloimmunization and hemoglobin F (Hb F) level. The total number of cohort study was 295 patients. Positive screening tests were further investigated to identify the type of Alloimmunized antibodies, including Rh, Kell, Kidd, Duffy, MNS and Lutheran, and other. which were identified using an ID gel card system. Among all 295 patients, 139 were males (47.1%) and 156 were females (52.9%). Alloantibodies were identified in 34 cases only (11.52%). The most frequent antibodies were anti-E, and anti-Kell There was a significant difference between total and alloimmunized patients in terms of age (p=0.0013.). The most frequent age was 20-40 years.. The number of males in alloimmunized patients was 14 (41.2%) and females, 20 (58.8%).
The prevalence of alloimmunization in Southern region is low compared to other regions of Saudi Arabia, USA, UK and Brazil. Increase in Hb F levels leads to decrease in blood transfusion rate. Patients with a blood type O have a greater chance of developing alloimmunization more than any other blood types. |
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Supervisor |
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Dr. Talaat Abdulkarim Mirza |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Co-Supervisor |
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Dr. Talal Hussein Qadah |
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Added Date |
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Sunday, June 3, 2018 |
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Researchers
| سلطان أحمد عسيري | Asiri, Sultan Ahmed | Researcher | Master | |
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