Document Details

Document Type : Thesis 
Document Title :
ULTRASTRUCTURAL STUDY ON THE EFFECT OF SILVER NANOPARTICLES ON SOME ORGANS OF MALE ALBINO MICE
دراسة تركيبية دقيقة لتأثير حبيبات الفضة متناهية الصغر على بعض الاعضاء في ذكور الفئران البيضاء
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : The study aimed to determine the effects that increased doses of nanoparticles can have on the structural properties of some vital organs in the body such as liver and kidneys in male albino mice. Sixty medium white male mice (20-25 g) were divided into 4 groups of different doses (15 mice in each group): control (saline solution), low-dose group was injected with 1000 mg/kg, medium dose group was injected with a dose of 2000 mg/kg and high dose group was injected with a dose of 4000 mg/kg. Samples were taken from each group after one week, two weeks and four weeks of injection. Then blood was collected from all animals for serum analysis of liver and kidney functions including hepatic and renal enzymes.The study of light microscopy showed tissue changes in liver and kidney membranes including programmed death and focal necrosis. One of the most significant effects was changes in nuclei that appeared either enlarged or bilateral in both liver and kidney cells. The study was confirmed by the transmission and scanning electron microscope, which was observed by optical microscope. The study concluded that despite the benefits of nanoparticles, it is important to test the safety of the use of different doses to determine the safe dose, especially on vital organs such as liver and kidney. 
Supervisor : Dr. Salim Mahmoud Abd Allah El-Hamidy 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Co-Supervisor : Dr. Abdul Kader Mohammed Shaikh Omar 
Added Date : Monday, June 4, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ريهام يوسف زاملZAMIL, REHAM YOUSEFResearcherMaster 

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