Document Details

Document Type : Thesis 
Document Title :
ANTIMICROBIAL ACTIVITY OF TIO2 NANOPARTICLES AGAINST PATHOGENIC STRAINS THAT CAUSE WOUND INFECTIONS
استخدام جزيئات أوكسيد التيتانيوم النانوي كمضاد ضد السلالات الممرضة التي تسبب التهابات الجروح
 
Subject : Faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : The first civilization dealt with disorders and provided detailed information about wound management was ancient Egyptians. Wound infections evidently appeared in times of World War I that accounted a significant mortality and morbidity rate among injured soldiers. Currently, around 11 million people worldwide require medical treatment for wound infections and 300,000 die every year due to untreated wound infection. The extensive use of antibiotics such as β-lactams, methicillin and vancomycin to treat wound infection leads to emerging new microbial strains that are resistant to many antibiotics. There is a growing concern on the emergence and re-emergence of drug-resistant pathogens such as multi-resistant bacterial strains. Hence, the development of new antimicrobial compounds or the modification of those that already exist to improve antibacterial activity is a high priority area of research. During the past few decades, nanotechnology has arisen with new promising technology for synthesis of nanobiomaterials. Metallic nanoparticles (NPs) are considered as a new alternative treatment that has antibacterial activity. In this study, the new formulation of titanium oxide (TiO2) NPs with different sizes were synthesized, characterized and their antibacterial activities against the causative agents of wound infection were studied. The NPs were characterized using X-Ray Diffraction (XRD) and Energy Dispersive X-Ray Spectroscopy (EDS). The antibacterial activity study was conducted using drop-plating method against three ATCC bacterial strains methicillin-resistant S. aureus (MRSA), E. coli and P. aeruginosa. The results confirmed that all TiO2 NPs exhibited high antibacterial activity against tested strains. The best antibacterial activity of TiO2 NPs was reported against MRSA and E. coli while the activity was quite restricted against P. aeruginosa. This study clearly illustrates a superior antibacterial activity of newly formulated NPs against the most causative agents of wound infection. This is will enhance the future of the therapeutic strategies against the resistant pathogenic strains that cause wound infections. 
Supervisor : Dr. Hani A. Alhadrami 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Added Date : Thursday, July 5, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
رانية أحمد شودريShoudri, Raniyah AhmadResearcherMaster 

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