Document Details

Document Type : Thesis 
Document Title :
UTILITY OF ACTIVE METHYLENE COMPOUNDS IN THE SYNTHESIS OF SOME NEW HETEROCYCLIC COMPOUNDS WITH EXPECTED BIOLOGICAL ACTIVITY
استخدام مركبات الميثيلين النشطة في تحضير بعض المركبات الحلقية غير المتجانسة الجديدة ذات النشاط البيولوجي المتوقع
 
Subject : Faculty of Sciences 
Document Language : Arabic 
Abstract : The present work represents the synthesis of a new series of highly functionalized 1-alkyl-6-amino-4-aryl (or het)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles 4a-q via one-pot three-component reaction of diverse aldehydes 2a-f, N-alkyl-2-cyanoacetamides 1a-c and malononitrile (3) in EtOH in the presence of K2CO3 as a base catalyst under thermal and microwave irradiation. The presented tandem process is expected to proceed via Knoevenagel condensation, Michael addition, intramolecular cyclization, autoxidation and subsequent aromatization. The structures of all the newly synthesized compounds in this work were unambiguously confirmed by IR, NMR (1H and 13C), mass spectral data and elemental analyses. 
Supervisor : Dr. Mariam Abdullah AL-Sheikh 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Added Date : Monday, July 9, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
نجلاء حسين السفيانيAlsofyani, Najla HosainResearcherMaster 

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