Document Details

Document Type : Thesis 
Document Title :
PREVALENCE OF OCCULT HBV AMONG HEMODIALYSIS PATIENTS
مدى انتشار التهاب الكبد الوبائي(ب) الخفي لدى مرضى غسيل الكلى
 
Subject : Faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : Prevalence of Occult HBV among Hemodialysis Patients in Jeddah-KSA By Amaal Ibrahim Barnawi Abstract Background: Occult HBV infection (OBI) is a silent form of hepatitis B infection, it is defined as the presence of HBV DNA in serum or liver tissue without detectable serological marker of hepatitis B surface antigen (HBsAg) with or without detectable of serological marker of hepatitis B core antibody (Anti-HBc IgG). Hepatitis B core antibody appears in the blood 1 to 4 weeks after contracting of the hepatitis B virus, and rises during the chronic phase, and remains present for patient’s life time. Thus, it is the most reliable serological marker to detect the presence of HBV infection when HBsAg is absent. Furthermore, Anti-HBc may represent OBI. On the other hand, sensitivity and specificity improvement of polymerase chain reaction (PCR) with detection limit of less than 10 IU/ml for HBV DNA led to identification of individuals who are carrying HBV DNA as the only marker of OBI. The main objective of this study, to determine the prevalence of hidden infection of hepatitis B virus among hemodialysis patients (HD). Materials and Methods: A total of 190 patients with end-stage renal disease on regular hemodialysis were included in this study, they were selected from King Abdulaziz University hospital and Hisham Attar centre for dialysis. All patients were passed the routine screening for HBsAg, hepatitis C antibody (Anti-HCV) and HIV Ag/Ab. All HBsAg-negative patients were tested for the presence of anti-HBc IgG by chemiluminescent microparticle immunoassay (CMIA). Then, all anti-HBc-positive patients were included for the presence of HBV-DNA by Real Time-PCR. Results: Mean age of studied patients was 55.2±12.105 years, our results showed that anti-HBc IgG were positive in 29.4 % of cases (N=56), from these patients 32.1 % (N=18) found to be positive for anti-HCV. HBV-DNA PCR was detected in 1 patient out of 56 and the viral load was less than 20 IU/ml. 
Supervisor : Dr. Laila Damanhoury 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Added Date : Thursday, July 19, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
آمال إبراهيم برناويBernawi, Amal IbrahimResearcherMaster 

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