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Document Type |
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Thesis |
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Document Title |
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PREVALENCE OF KELL BLOOD GROUP SYSTEM ANTIGENS K, K KPA, AND KPB IN JEDDAH توزيع نظام مجموعة فصائل الدم كيل أنتيجن K, k, Kpa and Kpb في مدينة جدة |
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Subject |
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Faculty of Applied Medical Sciences |
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Document Language |
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Arabic |
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Abstract |
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Prevalence of Kell Blood Group System Antigens K, k, Kpa, and Kpb in Jeddah Samaha Mubarak Bin Sumeda Abstract Background: The main aim of blood transfusion is to transfuse compatible blood, which will survive during and after transfusion. The selection of donor blood depends on the absence of antigen (Ag) against the corresponding antibody (Ab) that has been detected in patient serum. Kell blood group system is considered as the third clinically significant blood group (BG) in blood transfusion due to the highly immunogenicity of their antigens. Antigens and antibodies play a key role in hemolytic transfusion reaction (HTR); therefore, the transfusion services aim to provide a safe blood to the reception, which can be useful and functionally well after transfusion. The aim of The Study: The main goal of the study concentrates in creating data regarding the prevalence of Kell Ags by determining the K, k, Kpa and Kpb antigens and phenotypes among blood donors in Jeddah to improve medical care in transfusion services in the area. Subjects and Methods: A total of 758 donors were selected from different blood banks in Jeddah hospitals. Gel Card method was used, to perform Kell antigens typing. The data was analyzed by SPSS. Results: The most frequent Kell phenotype in this study is Kp(a-b+), followed by K-k+, K+k+, then Kp (a+b+), and the less frequent was K+k-. While there were no results for K-k-, Kp(a-b-) and Kp(a+b-) phenotypes. Conclusion: There was no study reported on Kell antigens and phenotypes distribution in Jeddah. This study was the first that set out to determine the prevalence of Kell antigens and phenotype among blood donors in Jeddah. To provide better care for patients by enhancing the additional tests to become routine tests in the blood bank. Recommendations: Reconsidering process Kell antigen typing test for both patients and donors and performed further studies about the prevalence of Kell blood group system antigens in Saudi Arabia. |
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Supervisor |
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Dr. Raed Felimban |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1440 AH
2019 AD |
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Added Date |
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Sunday, April 7, 2019 |
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Researchers
| سماحه مبارك سميدع | Sumeda, Samaha Mubarak | Researcher | Master | |
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