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Document Type |
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Thesis |
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Document Title |
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THE ALLOIMMUNIZATION OF BLOOD TRANSFUSION FOR SICKLE CELL AND THALASSEMIA PATIENTS IN KING ABDULAZIZ UNIVERSITY HOSPITAL اكتساب المناعة الغير ذاتي جراء نقل الدم لمرضى فقر الدم المنجلي ومرضى الثلاسيميا في مستشفى جامعة الملك عبدالعزيز |
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Subject |
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Faculty of Applied Medical Sciences |
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Document Language |
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Arabic |
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Abstract |
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Background: Thalassaemia and sickle cell disease (SCD) are considered to be the most common inherited disorders worldwide. To date, blood transfusion is the primary treatment for thalassaemia and SCD patients. However, this therapy carries a high risk of alloimmunisation to the transfused red blood cells (RBCs). Because of repetitive transfusion, a high risk of alloimmunisation may lead to haemolytic transfusion reactions (HTR) a serious complication. Aim of the study: This study is designed to determine the rates and specificities of alloimmunisation to blood group antigens (Ags) in SCD and thalassaemia patients, as well as to establish a blood database for SCD and thalassaemia patients according to serologic phenotype. Methodology: 104 SCD and 104 thalassaemia patients were screened for red cell alloantibodies. A special phenotype test was carried out on blood samples from these patients. Results: The alloimmunisation rates in SCA and thalassaemia patients were 39.42% and 35.60%, respectively. Rh and K were the main alloantibodies found in this patient sample. Among Rh alloantibodies, Anti-E is most prevalent in SCA and thalassaemia patients (in 29.33% and 45.6% of each group, respectively). The Rh and Kell RBC prevalence in SCD patients was as follows: C (69.23%), c (82.69%), E (25%), e (97.11%) and K (6.7%). In thalassaemia patients, the prevalence was: C (87.5%), c (93.26%), E (37.5%), e (99.03%) and K (5.76%). Conclusion: This study emphasises the need for phenotyping RBCs antigens prior to the first transfusion to SCD and thalassaemia patients, so as to provide the most compatible blood – especially for Rh and K antigens. This study also highlighted the most common RBC antibodies in patients with SCA and thalassaemia patients. Establishing local protocol for screening and identifying the red cell alloantibodies is a necessity to ensure the safety of these patients. |
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Supervisor |
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Dr. Salwa Hindawi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1440 AH
2019 AD |
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Added Date |
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Sunday, May 5, 2019 |
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Researchers
| ابرار طلال الحسني | Al Hassani, Abrar Talal | Researcher | Master | |
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