Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
The impact of vitamin D on the pathogenesis of Alzheimer's disease in experimental animals تأثير فيتامين د على النشوء المرضي لمرض الزهايمر في نموذج تجريبي |
|
Subject |
: |
Faculty of Medicine |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
Several studies have proven a correlation of diabetes with neurodegenerative diseases such Alzheimer's disease. Alzheimer's is associated with impairment of insulin signaling, glucose metabolism and oxidative stress pathway in the brain and this theory caused some researchers to indicate to Alzheimer disease as type 3 diabetes. Recently, clinical and animals studies have reported a potential beneficial role of vitamin D in cognitive function. The present study was designed to examine whether vitamin D3 has a protective effect against type 3 diabetes-induced cognitive dysfunction in rats. Moreover, possible underlying mechanisms were also investigated. Eighty-four male albino Westar rats (175g - 240g) were used in this study. Type 3 diabetes was induced by high-fat diet plus streptozotocin (40 mg/kg). Diabetic rats were divided into six subgroups, positive control (non-treated), vitamin D3 groups (100,500 and 1000 IU/kg/day), vitamin D3 plus rivastigmine and rivastgmine monotherapy. Treatment started after the onset of hyperglycemia for 4 months. Behavioral tests were used to assess cognitive function, followed by estimation levels of insulin, beta-amyloid-42, tau protein, neurotransmitters, oxidative stress, neuroinflammatory cytokines and neurotrophins in the hippocampus by ELIZA kits. Chronic treatment with vitamin D3 significantly and dose-dependently alleviated cognitive deficits assessed by the Morris water maze test (MWM), novel objective recognition task (NOR) and radial arm maze test (RAM) , with significant increase in the hippocampal levels of insulin, Glutathione, dopamine, Nerve growth factor, Neurotrophin-3, and Glial cell-derived neurotrophic factor levels. vitaminD3 administration for four months also significantly reduced the levels of Aβ, phosphorylated τ protein as underling mechanism for the resulted improvement. The present study shed the light on the potential protective effect of vitamin D3 against type 3 diabetes–induced cognitive dysfunction. |
|
Supervisor |
: |
Dr. May Ahmad |
|
Thesis Type |
: |
Doctorate Thesis |
|
Publishing Year |
: |
1440 AH
2019 AD |
|
Added Date |
: |
Monday, August 19, 2019 |
|
Researchers
| يحيى عبدالله الزهراني | AlZahrani, Yahya Abdullah | Researcher | Doctorate | |
|
Back To Researches Page
|