Document Details

Document Type : Thesis 
Document Title :
POLYMORPHISM OF XRCC3 AND XPD GENES AND RISK OF ACUTE LEUKEMIA.
تعدد الاشكال لجينات XRCC3 and XPD ومخاطرها المتعلقة بسرطان الدم الليمفاوي.
 
Subject : Faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : Background: There are many DNA repair mechanisms in our body that ensure the stability of DNA replication. These processes attempt to correct any damage to the DNA molecules. There are various mechanisms of repair, such as homologous recombination, non- homologous end joining and the repair of single strand breaks. Mutations in the genes encoding DNA repair proteins can lead to many diseases such as cancer (for example leukaemia) and hereditary neurological disorders. XRCC3 and XPD are two such proteins and many studies have linked mutations in these genes to cancers such as head and neck squamous cell carcinoma. Methods: Two single nucleotide polymorphisms (SNPs) in the XRCC3 and XPD genes (rs861539 and rs13181 respectively) were analysed in 55 Saudi patients with acute myeloid leukaemia (AML) and then compared to 100 disease free control subjects. In this project we will use DNA sequencing to determine if either of these SNPs are associated with AML. Until now no such association has been identified between XRCC3 and XPD genes and AML in patients from the Kingdom of Saudi Arabia. Results: A significant association (P ≤ 0.019) was detected between a polymorphism in the XRCC3 gene and the occurrence of AML, showing an increased risk of developing AML of 2.9 times. Also a polymorphism in the XPD gene had a nearly significant association (P ≤0.053) with AML and increased the risk of developing AML by 1.3 times. Conclusion: This study suggests that polymorphisms in the XRCC3 and XPD genes may contribute to an increased risk of developing AML in Saudi patients. 
Supervisor : Prof. Refaat Al-Fayoumi 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2019 AD 
Added Date : Sunday, November 24, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أفنان عثمان باحرثيBaharthi, Afnan OthmanResearcherMaster 

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