Document Details

Document Type : Thesis 
Document Title :
INVESTIGATION OF INFLUENZA A VIRUS CIRCULATION IN CAMELS IN SAUDI ARABIA
دراسة إنتشار فيروس الانفلونزا (أ) فى الجمال فى المملكة العربية السعودية
 
Subject : faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : Influenza viruses cause highly contagious respiratory tract infections. Influenza A viruses (IAV) represent a major global challenge to the health of both humans and animals as they are associated with regular epidemics and occasional pandemics due to their antigenic changes and wide host range. While interest in dromedary camels have increased after the emergence of the Middle East Respiratory Syndrome-Coronavirus (MERS-CoV), many aspects of their health have not been studied yet. Given that Saudi Arabia harbors thousands of camels and imports several other thousands from Africa every year, Herein, this research, investigate the possible circulation of IAV in dromedary camels in Saudi and genetically characterize identified viruses. A total of 665 nasal swabs (520 from imported camels and 145 from domestic camels) were collected from healthy (no overt illness) dromedary camels in Saudi Arabia between 2017 and 2018. Eleven specimens (1.7 %) were positive by real time PCR for IAV which were detected in imported camels only. Furthermore, partial genome sequencing suggested close relationship of detected viruses to human and swine influenza A H1N1 virus isolated from different countries between 2009 and 2018. Furthermore, detection of identical partial sequences of multiple samples obtained from camels arriving on the same shipments and the heterogeneity between sequences from camels imported on different time points suggest that camels could be unrecognized permissive host for influenza A virus. This study clearly highlights a need for enhanced surveillance for influenzas viruses as well as other pathogen in dromedary camels to better understand influenza ecology and epidemiology in these animals and evaluate their role in influenza emergence. 
Supervisor : Prof. Esam Ibraheem Azhar 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Co-Supervisor : Dr. Anwar Mohammed Hashem 
Added Date : Thursday, January 23, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبد العزيز علي الغامديAlghamdi, Abdel Azeez AliResearcherMaster 

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 45810.pdf pdf 

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